Registration Dossier
Registration Dossier
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EC number: 231-403-1 | CAS number: 7534-94-3
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- other: clinical case study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Documentation sufficient for assessment. Remark: small cohort
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 989
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- case report
- Principles of method if other than guideline:
- case reports, patch test
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Exo-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl methacrylate
- EC Number:
- 231-403-1
- EC Name:
- Exo-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl methacrylate
- Cas Number:
- 7534-94-3
- Molecular formula:
- C14H22O2
- IUPAC Name:
- 1,7,7-trimethylbicyclo[2.2.1]hept-2-yl methacrylate
- Details on test material:
- Purity not specified, but > 98% commercial grade assumed.
Constituent 1
Method
- Type of population:
- occupational
- Subjects:
- - Number of subjects exposed: 2
- Sex: no data
- Age: no data
- Race: no data - Route of administration:
- dermal
- Details on study design:
- 16 patients with or without previous handling experience with IBOMA containing materials, were patch tested with IBOMA (1%) according to standard methodology with Finn chambers on Scanpore.
Results and discussion
- Results of examinations:
- Results of patch testing with Isobornyl methacrylate (1 %) showed 2 of 2 patients with negative reactions.
No positive reactions were observed. 2 of 2 tested patients showed a negative patch test reaction to IBOMA (patch test concentration: 1%).
Applicant's summary and conclusion
- Conclusions:
- No positive reactions were observed. 2 of 2 tested patients showed a negative patch test reaction to IBOMA (patch test concentration: 1%).
- Executive summary:
16 patients with skin and nail reactions to acrylics from 1978 to 1987 were evaluated. There were 13 females and
three males (age 22 - 62 years). Five were atopic. Eleven were occupational. The 5 cases which were not occupationally caused included four of the five nail cases and one case with a denture reaction.
Thirteen had contact dermatitis, two nail dystrophy, and one had both contact dermatitis and nail dystrophy. Of the 14 cases of contactdermatitis, 11 were allergic, one was irritant and two were not determined.
Most were patch-tested according to standard methodology with Finn chambers on Scanpore. Patch testing was usually performed withthe standard screening series of the North American Contact Dermatitis Group (NACDG) and one or more acrylic chemicals. Acrylics
were tested in petrolatum (pet.). Results of patch testing with Isobornyl methacrylate (1 %) showed 2 of 2 patients with negative reactions.
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