Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 480-280-2 | CAS number: 2232-12-4
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- repeated dose toxicity: oral
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 96/54/EG, B.7; OECD 407 (1995)
- GLP compliance:
- yes
- Limit test:
- no
Test animals
- Species:
- other: rat, Wistar Hsd Cpb:WU
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- other: diet
- Details on oral exposure:
- Method of administration:
diet - Duration of treatment / exposure:
- Test duration: 28 days
- Frequency of treatment:
- Dosing regime: 7 days/week
- No. of animals per sex per dose:
- Male: 10 animals at 0 mg/kg bw/day
Male: 10 animals at 9.5 mg/kg bw/day
Male: 10 animals at 97 mg/kg bw/day
Male: 10 animals at 963 mg/kg bw/day
Female: 10 animals at 0 mg/kg bw/day
Female: 10 animals at 10.9 mg/kg bw/day
Female: 10 animals at 108 mg/kg bw/day
Female: 10 animals at 1093 mg/kg bw/day
Results and discussion
Results of examinations
- Details on results:
- Clinical observations:
There were no mortalities during the course of the study No
treatment-related clinical signs were recorded throughout
the treatment period in either sex. Body weigt and food
consumption were unaffected in any dose group in either sex.
Effects in organs:
Hematological investigations and clinical biochemistry did
not show changes of toxicological relevance at any dose
level in either sex. Mean terminal body weights revealed no
relevant changes when compared to controls. Decreased organ
weights of the pituitary in all male treatment groups in
comparison to control organs were not found to be of
toxicological relevance, because this change was not found
to be dose related and not associated with relevant
histopathological changes.
Effect levels
- Dose descriptor:
- NOEL
- Effect level:
- 963 mg/kg bw/day (nominal)
- Basis for effect level:
- other: original NCD unit is mg/kg/day.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Classified as: Not classified
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
