2,4-Imidazolidinedione, 1,3-diiodo-5,5-dimethyl-

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Adequacy of study:

other information

Data source

Reference

Reference Type:

other: Body responsible for the test

Title:

Unnamed

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: 92/69/EWG, B.3; OECD 402 (1987)

GLP compliance:

yes

Limit test:

no

Test animals

Species:

other: rat, Wistar Hsd Cpb:WU

Administration / exposure

Type of coverage:

semiocclusive

Vehicle:

water

Duration of exposure:

24 h

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 400 mg/kg bw

Mortality:

Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 5
Female: 400 mg/kg bw; Number of animals: 5; Number of deaths: 0

Clinical signs:

other: Signs of toxicity related to dose levels: Clinical signs: piloerection, pallor, decreased motility, abdominal position, narrowed palpebral fissure and laboured breathing (2000, 400 mg/kg).

Gross pathology:

Effects on organs:
2000 mg/kg bw:

Females which died:

partial induration, black discoloration of the skin at the
treatment area, spotted liver.

Sacrificed males:

partial induration, skin detachment and brownish-black
discoloration of the skin.


400 mg/kg; females:

partial induration, skin detachment, brownish-red
discoloration of the skin, partly ecrustation.

Other findings:

Signs of toxicity (local):
Partial induration, encrustation and formation of scale,
partial detachment of the skin and black / red-brown
discolourations at the site of treatment (2000, 400 mg/kg).

Applicant's summary and conclusion

Interpretation of results:

harmful

Remarks:

Migrated information Criteria used for interpretation of results: EU