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EC number: 209-711-2 | CAS number: 591-27-5
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from authoritative database (J check)
- Qualifier:
- according to guideline
- Guideline:
- other: "Bioaccumulation test of a chemical substance in fish or shellfish" provided in "the Notice on the Test Method Concerning New Chemical Substances"
- Principles of method if other than guideline:
- BCF values of test chemical is determined in fish Cyprinus carpio for 6 weeks on the basis of whole body weight.
- GLP compliance:
- not specified
- Radiolabelling:
- not specified
- Details on sampling:
- sampling were done after 2, 3, 4 and 6 weeks
- Vehicle:
- not specified
- Test organisms (species):
- Cyprinus carpio
- Route of exposure:
- aqueous
- Water / sediment media type:
- natural water: freshwater
- Details on test conditions:
- RANGE-FINDING / PRELIMINARY STUDY - Test concentrations : TLm(48h) 100 ppm(w/v), Rice fish (Oryzias latipes)
- Nominal and measured concentrations:
- - Nominal concentrations 1st Concentration area: 1 mg/L, 2nd Concentration area: 0.1 mg/L
- Conc. / dose:
- 1 mg/L
- Type:
- BCF
- Value:
- 4 L/kg
- Basis:
- whole body w.w.
- Time of plateau:
- 6 wk
- Remarks on result:
- other: other details not available
- Conc. / dose:
- 0.1 mg/L
- Type:
- BCF
- Value:
- 40 L/kg
- Basis:
- whole body w.w.
- Time of plateau:
- 6 wk
- Remarks on result:
- other: other details not available
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The bioconcentration factor (BCF) for test chemical was determined according static fish test. The BCF value was observed to 4 L/kg at dose concentration 1 mg/L and 40 L/kg at dose concentration 0.1 mg/L on test organism Cyprinus carpio during 6 weeks period. On the basis of BCF values it is concluded that test chemical is non bioaccumulative.
- Executive summary:
Bioaccumulation test was conducted for 8 weeks for determination the bioconcentration factor (BCF) of test chemical on test organism Cyprinus carpio.Nominal concentrations used in the study are 1st Concentration area: 1 mg/L, 2nd Concentration area: 0.1 mg/L and Range finding study was carried out on Rice fish (Oryzias latipes) TLm(48h) 100 ppm(w/v). Thus the bioconcentration factor (BCF) for test chemical was determined according static fish test. The BCF value was observed to 4 L/kg at dose concentration 1 mg/L and 40 L/kg at dose concentration 0.1 mg/L on test organism Cyprinus carpio during 6 weeks period. On the basis of BCF values it is concluded that test chemical is non bioaccumulative.
Reference
|
2 W |
3 W |
4W |
6W
|
|
1st Concentration area
|
Test substance concentration mg/L |
1.27 |
1.12 |
1.09 |
1.10 |
Bioconcentration factor L/kg |
<= 4 |
<= 4 |
<= 4 |
<= 4 |
|
<= 4 |
<= 4 |
<= 4 |
<= 4 |
||
2nd Concentration area
|
Test substance concentration mg/L |
0.104 |
0.095 |
0.097 |
0.094
|
Bioconcentration factor L/kg |
<= 40 |
<= 40 |
<= 40 |
<= 40 |
|
<= 40 |
<= 40 |
<= 40 |
<= 40 |
||
Description of key information
Bioaccumulation test was conducted for 8 weeks for determination the bioconcentration factor (BCF) of test chemical on test organism Cyprinus carpio.Nominal concentrations used in the study are 1st Concentration area: 1 mg/L, 2nd Concentration area: 0.1 mg/L and Range finding study was carried out on Rice fish (Oryzias latipes) TLm(48h) 100 ppm(w/v). Thus the bioconcentration factor (BCF) for test chemical was determined according static fish test. The BCF value was observed to 4 L/kg at dose concentration 1 mg/L and 40 L/kg at dose concentration 0.1 mg/L on test organism Cyprinus carpio during 6 weeks period. On the basis of BCF values it is concluded that test chemical is non bioaccumulative.
Key value for chemical safety assessment
Additional information
Bioaccumulation test was conducted for 8 weeks for determination the bioconcentration factor (BCF) of test chemical on test organism Cyprinus carpio.Nominal concentrations used in the study are 1st Concentration area: 1 mg/L, 2nd Concentration area: 0.1 mg/L and Range finding study was carried out on Rice fish (Oryzias latipes) TLm(48h) 100 ppm(w/v). Thus the bioconcentration factor (BCF) for test chemical was determined according static fish test. The BCF value was observed to 4 L/kg at dose concentration 1 mg/L and 40 L/kg at dose concentration 0.1 mg/L on test organism Cyprinus carpio during 6 weeks period. On the basis of BCF values it is concluded that test chemical is non bioaccumulative.
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