3-aminophenol

Adsorption / desorption

Link to relevant study record(s)

Reference

Endpoint:

adsorption / desorption

Remarks:

adsorption

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: data is frrom peer reviewed journal

Justification for type of information:

data is frrom peer reviewed journal

Qualifier:

according to guideline

Guideline:

other: HPLC Estimation

Principles of method if other than guideline:

The sorption of test chemical on granular goethite (30-50 mesh) was investigated. The samples were filtered and analyzed by HPLC UV-VIS

GLP compliance:

not specified

Type of method:

HPLC estimation method

Media:

other: water-solid surface

Specific details on test material used for the study:

- Name (IUPAC): 1-Hydroxy-3-amino-benzene
- Name of test material (as cited in study report): 3-Aminophenol
- Molecular formula: C6H7NO
- Molecular weight: 109.127 g/mol
- Smiles notation: c1c(cccc1O)N
- InChl : 1S/C6H7NO/c7-5-2-1-3-6(8)4-5/h1-4,8H,7H2
- Substance type: Organic
- Physical state: solid

Radiolabelling:

not specified

Test temperature:

25°C

Details on study design: HPLC method:

Sorption on granular goethite (30-50mesh) was investigated; pH 6.0; temparature range 20-35 deg C; goethite at concentration 0.003 g/l and initial title comp. at concentration 0.00001 mol/l were suspended; samples were filtered and analyzed by HPLC UV-VIS.

HPLC: Hewlett–Packard 1100 HPLC equipped with a UV-VIS diode array detector and a Phenomenex C6 reverse phase column was used

Key result

Type:

other: % sorption

Value:

4 other: percent

pH:

6

Temp.:

25 °C

Matrix:

geothite

Remarks on result:

other: at temperature range 20-35 oC

Details on results (HPLC method):

Fractional sorption of approx 4 percent was detected.

Transformation products:

not specified

Validity criteria fulfilled:

not specified

Conclusions:

Adsorption studies were conducted using initial concentration 0.00001 mol/L of test chemical at 25°C. Adsorption, in terms of sorption on granular goethite (30-50 mesh) was investigated with goethite at concentration 0.003 g/L. Both goethite and test susbtance were suspended in water. Samples were filtered and analysed by HPLC, UV-VIS. The fractional sorption of test chemical was calculated as 4 %. This value indicates the low adsorption potential of the chemical.

Executive summary:

Adsorption studies were conducted using initial concentration 0.00001 mol/L of test chemical at 25°C. Adsorption, in terms of sorption on granular goethite (30-50 mesh) was investigated with goethite at concentration 0.003 g/L. Both goethite and test susbtance were suspended in water. Samples were filtered and analysed by HPLC, UV-VIS. The fractional sorption of test chemical was calculated as 4 %. This value indicates the low adsorption potential of the chemical.

Description of key information

Adsorption studies were conducted using initial concentration 0.00001 mol/L of test chemical at 25°C. Adsorption, in terms of sorption on granular goethite (30-50 mesh) was investigated with goethite at concentration 0.003 g/L. Both goethite and test susbtance were suspended in water. Samples were filtered and analysed by HPLC, UV-VIS. The fractional sorption of test chemical was calculated as 4 %. This value indicates the low adsorption potential of the chemical.

Key value for chemical safety assessment

Koc at 20 °C:

90

Additional information

Experimental studies for test chemical have been reviewed for adsorption endpoint and their results are summarized below.

 

The first experimental study was reviewed from journal Water Research (2002) in this study the adsorption in soil was determined using initial concentration 0.00001 mol/L of test chemical at 25°C. Adsorption, in terms of sorption on granular goethite (30-50 mesh) was investigated with goethite at concentration 0.003 g/L. Both goethite and test substance were suspended in water. Samples were filtered and analysed by HPLC, UV-VIS. The fractional sorption of test chemical was calculated as 4 %. This value indicates the low adsorption potential of the test chemical.

 

Next both the studies were reviewed from authoritative database (HSDB, 2018) in first study the Koc value for test chemical was estimated by using a structure estimation method based on molecular connectivity indices. The estimated Koc value was 90 dimensionless and log Koc is 1.9542 this log Koc value suggests that test chemical is expected to have low sorption to soil and sediment and therefore have moderate migration potential to ground water.

 

In another study the percent adsorption of test chemical on organoclay is 12% at pH 7.7. On the basis of percent adsorbed of test chemical it can be concluded that test chemical has low sorption to organoclay and moderate migration potential to ground water.

 

 By considering results of all the studies mentioned above it can be concluded that test chemical  has low sorption to soil and sediments and therefore has moderate migration potential to ground water.