1-vinylhexahydro-2H-azepin-2-one

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Study is comparable with the inhalation hazard test described in the Annex of OECD Guideline 403 (adopted 1981) with acceptable restrictions mostly due to reduced documentation and no GLP

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1963

Report date:

1963

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Deviations:

yes

Remarks:

Analytical purity of the test substance not reported

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

1-vinylhexahydro-2H-azepin-2-one

EC Number:

218-787-6

EC Name:

1-vinylhexahydro-2H-azepin-2-one

Cas Number:

2235-00-9

Molecular formula:

C8H13NO

IUPAC Name:

1-vinylazepan-2-one

Details on test material:

- Name of test material: N-vinylcaprolactam dest.

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Mean weight at study initiation: 160.5 g (calculated from the raw data)

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

air

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
Vapour was generated by bubbling 200 l/h dry air (no CO2) through the test substance column of about 5 cm above a fritted glass disc in a glass cylinder. The glass cylinder was heated in a water bath to two different temperatures, 20 and 50°C. Concentrations stated in the raw data were 1.12, 1.36 and 1.6 mg/L generated by heating the water bath to 50°C, and 0.2 and 0.3 mg/L generated by heating the water bath to 20°C.

Analytical verification of test atmosphere concentrations:

yes

Duration of exposure:

8 h

Concentrations:

0.2, 0.3, 1.12, 1.36 and 1.6 mg/L

No. of animals per sex per dose:

3

Control animals:

no

Details on study design:

- Duration of observation period following administration: 7 days
- Frequency of observations and weighing: clinical signs were recorded several times on the day of administration and at least once per workday for the individual animals; weighing on day 0 before administration.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, mean body weight

Statistics:

not performed

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 1.6 mg/L air (nominal)

Based on:

test mat.

Exp. duration:

8 h

Mortality:

No mortality was observed.

Clinical signs:

other: No clinical signs were observed.

Body weight:

No effect on the body weight gain was observed.

Gross pathology:

No abnormalities were noted.