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EC number: 218-787-6 | CAS number: 2235-00-9
Five healthy male and five healthy female New Zealand Albino rabbits were dosed dermally with the test substance at 1000, 1600, 2000 and 2500 mg/kg of body weight. The test article was kept in contact with the skin for 24 hours. Dermal responses were recorded on days 1, 7 and 14. Animals were observed for toxicity and pharmacological effects at 1, 2 and 4 hours post dose and once daily for 14 days. All animals were observed twice a day for mortality. Body weights were recorded pretest, weekly and at death or termination in the survivors. All animals were examined for gross pathology. The deaths occurred by day 4 and were preceded by physical signs of diarrhea, lethargy, ptosis, dyspnea, negative righting reflex, ataxia, few feces, yellow nasal discharge, red discharge and soiling of the anogenital area, convulsions and mucoid diarrhea. Necropsy of the dead animals revealed abnormalities of the lungs, liver, spleen, pleural cavity, eyes, treated skin, kidneys, heart and gastrointestinal tract, as well as soiling of the anogenital area, wetness of the nose/mouth area, wetness of the anogenital area and red staining of the anogenital area. Physical signs noted in survivors included lethargy, ptosis, yellow nasal discharge, diarrhea, ataxia, dyspnea, few feces, emaciation, soiling of the anogenital area, red discharge, ocular discharge, red staining of the anogenital and mucoid diarrhea. Body weight changes of survivors were generally normal, although instances of weight loss were noted in survivors of all groups. Necropsy results of survivors revealed abnormalities of the treated skin, gastrointestinal tract, lungs, liver and kidneys. The LD 50's and 95 Confidence Limits are: males · 1700 (1300 · 2200) mg/kg; females · 1800 (1300 · 2500) mg/kg; and males & females combined · 1700 (1300 - 2200) mg/kg.
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