Registration Dossier
Registration Dossier
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EC number: 931-485-5 | CAS number: -
Endpoint summary
Administrative data
Description of key information
-Skin irritation: not irritating, not corrosive in vitro
-Eye irritation: severely irritant in vitro
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
In the available relevant in vitro results obtained with the reaction mass containing mainly 2-chloropropene, it was demonstrated that the reaction mass was
-not irritant in the skin irritation test
-not corrosive in the skin corrosion test
-severely irritant or corrosive in the bovine corneal opacity and permeability test.
No information is available on the respiratory irritation for the reaction mass containing mainly the 2-chloropropene. However, as the 3-chloropropene which is one of the substance constituting the mixture is officially classified as a respiratory irritant (STOT SE 3/H335 according to CLP legislation), it was taken into account to propose the classification.
Effects on eye irritation: highly irritating
Effect level: empty Endpoint conclusion: Adverse effect observed
Justification for classification or non-classification
Skin and Eye irritation:
Based on the above in vitro results, we propose the following classification:
-R36 (irritating to eyes) according to DSD legislation
-Eye irritation Cat 2/H319 (Causes serious eye irritation) according to CLP legislation.
No classification is needed for the skin irritation endpoint.
Respiratory irritation:
Depending on the batch, the proportion of some of the impurities as 3 -chloropropene may vary. Some of the samples contains up to 0.5% in 3-chloropropene while other contains up to 5% of the same substance. As the percentage of 3-chloropropene reach maximum 5%, we should not classified the reaction mass containing mainly 2-chloropropene for this endpoint according to the mixtures's criterias of CLP-DSD legislation.
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