Reaction mass of (Z)-1-chloro-1-propene and 2-chloropropane and 2-chloropropene

Water solubility

Administrative data

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

June 2010

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP study performed according to OECD guideline 105 and EU Method A.6

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2010

Report date:

2010

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Remarks:

Food and Consumer Product Safety Authority (VWA), The Netherlands

Type of method:

flask method

Test material

Test material information

Constituent 1

Reference substance name:

2-chloropropene

EC Number:

209-187-5

EC Name:

2-chloropropene

Cas Number:

557-98-2

Molecular formula:

C3H5Cl

IUPAC Name:

2-chloroprop-1-ene

Constituent 2

Reference substance name:

2-chloropropane

EC Number:

200-858-8

EC Name:

2-chloropropane

Cas Number:

75-29-6

Molecular formula:

C3H7Cl

IUPAC Name:

2-chloropropane

Constituent 3

Reference substance name:

1-chloropropene

EC Number:

209-675-8

EC Name:

1-chloropropene

Cas Number:

590-21-6

IUPAC Name:

1-chloroprop-1-ene

Details on test material:

Identification Reaction mass containing mainly 2-chloropropene
Molecular formula C3H5Cl
Molecular weight 76.53
CAS Number 557-98-2
Description Clear light yellow to brown liquid (determined at NOTOX)
Batch RBA100301A
Purity Minimum 60.0%
Test substance storage In refrigerator (2-8°C) in the dark
Stability under storage conditions Stable
Expiry date 08 March 2011 (allocated by NOTOX, 1 year after receipt of the test substance)

Results and discussion

Water solubility

Water solubility:

1.94 g/L

Temp.:

20 °C

pH:

>= 3.1 - <= 3.5

Any other information on results incl. tables

Preliminary test

The content of test substance dissolved in the water sample with a stirring time of 21 hours was 1.83 g/l.

 

Main study

The results for the samples taken at 24, 48 and 72 hours are given inTable9.

 

The 72-hour measurement was somewhat lower than the 24- and 48- hour measurements (maximum difference > 15%). A possible reason for it could be that the test substance had been degraded and/or evaporated from the water phase during performance of the test.

 

According to the guidelines, the water solubility of the test substance is given as the mean value of the 24- and 48-hour measurements. The maximum difference on these values was < 15%.

 

No test substance was detected in the pretreated samples from the blank water mixture.

 

Table9           Main study - water solubility of the test substance

Stirring time [hours]	Analysed concentration [g/l]	Mean^# [g/l]	MD^# [%]	pH
24	2.07	1.94	13	3.5
48	1.81			3.3
72	1.73			3.1

^#        Based on the 24 and 48 hours samples.

 

Applicant's summary and conclusion

Conclusions:

Interpretation of results (migrated information): soluble (1000-10000 mg/L)
The flask method was chosen for the determination of the water solubility of the reaction mass containing mainly 2-chloropropene. Quantification was performed on the major compound of the test substance.

The water solubility of the test substance at 20°C was 1.94 g/l. The pH of the aqueous samples was 3.1 to 3.5.