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Short-term toxicity to fish

Diethylamine is with high probability acutely not harmful to fish.

key study: Oryzias latipes, OECD 203, GLP, semi-static test conditions, analytically verified test concentrations, in addition to non-adjusted test solutions, pH value adjusted for highest test concentration (NITE 2000, report no.: NMMP/E99/4070): 96 -h LC50 = 26.7 mg/L (for non-neutralised test solutions, nominal, 95% CL: 19.7 - 34.8 mg/L); 96 -h LC50 > 100 mg/L (for neutralised test solutions, nominal)

supporting studies (publications):

- Calamari et al. (1980): Oncorhynchus mykiss, italian standard guideline, LC50 = 182 mg/L (nominal, analytically verified, in hard water), LC50 = 25 mg/L (nominal, analytically verified, in soft water)

- Brooke et al. (1984): Pimephales promelas, standard methods acc. to APHA, analytically verified test concentrations, pH-adjustment of the test solutions: 96 -h LC50 = 855 mg/L (nominal)

- van Leeuwen et al. (1985): Poecilia reticulata, OECD 203, semi-static test conditions: 96 -h LC50 = 130 mg/L (nominal)

other information:

- Tonogai et al. (1982): Oryzias latipes, Japanese Industrial Standards Commitee, JIS K0102, no analytical verification, pH-adjustment of the test solutions: 48 -h LC50 = > 1000 mg/L (nominal)

Long-term toxicity to fish

In Annex IX, Section 9.1.6, Column 2 of Regulation (EC) No 1907/2006, it is laid down that long-term toxicity testing on fish shall be proposed by the registrant if the chemical safety assessment indicates the need to investigate further the effects on fish. According to Annex I of this regulation, the chemical safety assessment triggers further action when the substance or the preparation meets the criteria for classification as dangerous according to CLP-Regulation (EC) No 1272/2008 and its second adaptation 286/2011 or is assessed to be a PBT or vPvB.  The hazard assessment of the substance reveals neither a need to classify the substance as dangerous to the environment, nor is it a PBT or vPvB substance, nor are there any further indications that the substance may be hazardous to the environment.   In Annex XI, Section 3, it is laid down that testing in accordance with Annex IX and Annex X may be omitted, based on the exposure scenario(s) developed in the Chemical Safety Report (“Substance-Tailored Exposure-Driven Testing”). In accordance with Annex XI Section 3, it can be demonstrated in the risk assessment that the manufacture and the use of the substance do not pose an unacceptable risk for all environmental compartments as the risk characterization ratios (RCRs) of the chemical safety assessment are below 1 for all compartments (see Chemical Safety Report Ch. 10). Therefore, and for reasons of animal welfare, a long-term toxicity test on fish is not provided.

Short-term toxicity to aquatic invertebrates

Diethylamine is acutely toxic to aquatic invertebrates.

key study: Ceriodaphnia dubia, ASTM guideline (1993), GLP, semi-static test conditions, analytically verified concentrations, non-adjusted pH values (Arkema 1994, report no.: 94 -6 -5329): 48 -h LC50 = 4.6 mg/L (95% CL: 3.1 - 6.7 mg/L, based on measured test concentrations), 48 -h NOAEL = 3.1 mg/L (based on measured test concentrations)

supporting studies (publications):

- van Leeuwen et al. (1985): Daphnia magna; OECD 202, semi-static test conditions: 48 -h EC50 = 56 mg/L (nominal, 95% CL: 32.0 - 100 mg/L)

- NITE, 2000: Daphnia magna; OECD 202, GLP, analytically verified test concentrations, no pH-adjustment of the test solutions; 48 -h EC50 = 58 mg/L (95% CL: 49.9 - 68.1 mg/L; measured geomean concentrations, test solutions were not neutralised)

- Bringman & Kuehn, 1959: Daphnia magna, static test conditions, no analytical monitoring: 48- h EC50 = 100 mg/L (nominal)

other information:

- Trenel & Kuehn, 1982: Daphnia magna, analytical verification of test concentrations; 24 -h EC50 = 77 mg/L (nominal, for non-neutralised samples): 24 -h EC50 = 288 mg/L (nominal, for neutralised samples)

- IRCHA ED, 1993: Daphnia magna, AFNOR T 90301 (1974), non-GLP, no analytical verification: 24 -h EC50 = 41 mg/L

- Calamari, 1980: Daphnia magna, AFNOR 90301 (1974), non-GLP, analytical verification of test concentrations: 24 -h EC50 = 164 mg/L (nominal)

Long-term toxicity to aquatic invertebrates

The chronic 21 -d EC10 based on reproduction for Daphnia magna was determined to be 4.1 mg/L.

key study: Daphnia magna, OECD 211, GLP, analytically verified test concentrations, pH values not adjusted (NITE, 1999, report no.: NMMP/E99/3070): 21 -d EC50 (reproduction) = 6.01 mg/L (95% CL: 4.85 - 7.13 mg/L; based on measured concentrations; recalculated value; BASF SE 2020), 21 -d EC10 (reproduction) = 4.07 mg/L (95% CL: 2.25 - 4.99 mg/L; based on measured concentrations, recalculated value, BASF SE 2020)

supporting study: Ceriodaphnia dubia, ASTM (1993), GLP, analytically verified test concentrations, pH values not adjusted (Arkema 1994, report no.: 94 -7 -5330); subchronic test according to REACH Guidance Document R.7b (v4.0, June, 2017, p. 98): 7 -d NOEC (mortality) = 1.7 mg/L (based on measured concentrations)

Toxicity to aquatic algae and cyanobacteria

Diethylamine is acutely harmful to algae.

key study: Pseudokirchneriella subcapitata, OECD 201, GLP, analytically verified test concentrations (NITE 2000, report no.: EMMP/E99/1070): 72 -h ErC50 = 50.9 mg/L (95% CL: 49.3 - 52.4 mg/L; based on measured geomean concentrations, recalculated value, BASF SE 2020), 72 -h ErC10 = 34.3 mg/L (95% CL: 32.0 - 36.3 mg/L, based on measured geomean concentrations, recalculated value, BASF SE 2020)

supporting studies (publications):

- Calamari et al. (1980): Pseudokirchneriella subcapitata; EPA 1971; 96 -h EC50 based on fluometric values = 20 mg/L (nominal, analytically verified)

- van Leeuwen et al. (1985): Chlorella pyrenoidosa; 96 -h ErC50 = 56 mg/L (nominal)

Toxicity to microorganisms

The inhibition of the degradation activity of activated sludge is not anticipated when introduced in appropriate low concentrations.

key study: municipal activated sludge, ISO 8192, non-GLP (BASF AG, 1990, report no.: 01.89/0742): 30 -min EC10 > 1000 mg/L (nominal)

supporting study: Pseudomonas putida, DIN 38412 part 8, non-GLP, no adjustment of pH except for two additional test concentrations (125 and 1000 mg/L; BASF AG, 1989, report no.: 9/1890742): 17 -h EC10 = 35 mg/L (nominal, for non-neutralised test concentrations); 17 -h EC10 > 1000 mg/L (nominal, for neutralised test concentrations).