Registration Dossier
Registration Dossier
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EC number: 203-716-3 | CAS number: 109-89-7
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The test substance is with high probability acutely not harmful to fish.
Key value for chemical safety assessment
Additional information
Under supervision of the Japanese Ministry of the Environment an acute fish test according to OECD 203 was conducted under GLP and published in 2000. The test species was Oryzias latipes. The fish were exposed for 96 hours under semi-static conditions to nominal test concentrations of 9.5 to 100 mg/L diethylamine. The test concentrations were analytically verified.
The test solutions without pH-adjustment showed initial pH values between 9.1 and 10.6. The acceptable pH range for fish given in the OECD TG 203 (6.0 to 8.5) was only kept in the control, while the test solutions showed initial pH values above 8.5. Therefore, the highest test concentration (100 mg/L) was also tested with neutralised pH value. A 96 -h LC50 was determined for non-neutralised samples to be 26.7 mg/L (95% CL: 19.7 - 34.8 mg/L, nominal). In the neutralised highest test concentration of 100 mg/L no fish died during the 96 -h of exposure (96 -h LC50 > 100 mg/L, for neutralised test solutions, NITE, 2000, report no.: NMMP/E99/4070).
These results are supported by further publications:
- Brooke et al. (1984): Pimephales promelas, standard methods acc. to APHA, analytically verified test concentrations, pH-adjustment of the test solutions: 96 -h LC50 = 855 mg/L (nominal)
- van Leeuwen et al. (1985): Poecilia reticulata, OECD 203, semi-static test conditions: 96 -h LC50 = 130 mg/L (nominal)
other information:
- Tonogai et al. (1982): Oryzias latipes, Japanese Industrial Standards Commitee, JIS K0102, no analytical verification, pH-adjustment of the test solutions: 48 -h LC50 = > 1000 mg/L (nominal)
Therefore, it was concluded that diethylamine is with high probability acutely not harmful to fish.
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