Magnesium acrylate

Endpoint summary

Description of key information

Kinetic parameters for acrylic acid oxidation in isolated mouse and rat tissue of liver, kidney and skin were determined. All tissues were able to oxidize acrylic acid to a certain extent, but with considerable variation. The kidney and the liver were the organs showing the highest oxidation rates. Acrylic acid was rapidly absorbed and eliminated after single oral doses. Exhalation of 14CO2 was the major route of elimination, accounting for approximately 80-90% of the administered dose (94% of recovered radioactivity) after either dose level. This process was rapid and nearly complete within 8 h after administration. A somewhat slower rate of 14CO2 exhalation after the latter dose appeared to reflect slower absorption of the bolus dose. Less than 2% of the dose remained in tissues or carcass 72 h after dosing. Urinary excretion accounted for about 3-4% of the dose, with most occurring over the first 24 h. Excretion in faeces accounted for less than 0.2% of the dose. Only trace amounts of exhaled organic volatile compounds other than 14CO2 were detected. The rates of acrylic acid oxidation in tissues from male and female mice were similar. Following an oral dose of [14C]acrylic acid to rats, a rapid elimination was noted. Within 8 hr 35-60% of the dose was eliminated from the animals with most of the elimination occurring as expired carbon dioxide. By 24 hr 50-65% of the dosed radioactivity had been eliminated, and the excretion of radioactivity had virtually ceased. This information can be used for read across to Magnesium acrylate. See justification in the attached read across justification document to the CSR.

Key value for chemical safety assessment

Bioaccumulation potential:

no bioaccumulation potential

Absorption rate - oral (%):

100

Absorption rate - dermal (%):

100

Absorption rate - inhalation (%):

100