N-isopropyl-N'-phenyl-p-phenylenediamine

Dermal absorption

Administrative data

Endpoint:

dermal absorption in vivo

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: publication does not give sufficient experimental details

Data source

Reference

Reference Type:

publication

Title:

Excretion kinetics of the rubber anti-oxidant N-isopropyl-N'-phenyl-p-phenylenediamine

Author:

Scansetti G et al.

Year:

1987

Bibliographic source:

International Archives Occupational Environmental Health 59, 537-543

Materials and methods

Principles of method if other than guideline:

other: skin absorption study with human volunteer

Test material

Test material information

Constituent 1

Reference substance name:

N-isopropyl-N'-phenyl-p-phenylenediamine

EC Number:

202-969-7

EC Name:

N-isopropyl-N'-phenyl-p-phenylenediamine

Cas Number:

101-72-4

Molecular formula:

C15H18N2

IUPAC Name:

N1-phenyl-N4-(propan-2-yl)benzene-1,4-diamine

Test animals

Species:

human

Results and discussion

Percutaneous absorption

Percutaneous absorption 1

Dose:

2g/10l

Remarks on result:

other: 90 min

Remarks:

No IPPD present in urine

Percutaneous absorption 2

Dose:

2g/10l

Remarks on result:

other: 3 h

Remarks:

100 µg/l IPPD in urine

Percutaneous absorption 3

Dose:

2g/10l

Remarks on result:

other: 5 h

Remarks:

350 µg/l IPPD in urine

Percutaneous absorption 4

Dose:

2g/10l

Remarks on result:

other: 10.5 h

Remarks:

570 µg/l IPPD in urine

Any other information on results incl. tables

After 105 h max. exctretion peak, the excretion began to drop, ahowing three consecutive slopes; excretion ceased 7 d after exposure.