Registration Dossier
Registration Dossier
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EC number: 202-969-7 | CAS number: 101-72-4
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: publication does not give sufficient experimental details
Data source
Reference
- Reference Type:
- publication
- Title:
- Excretion kinetics of the rubber anti-oxidant N-isopropyl-N'-phenyl-p-phenylenediamine
- Author:
- Scansetti G et al.
- Year:
- 1 987
- Bibliographic source:
- International Archives Occupational Environmental Health 59, 537-543
Materials and methods
- Principles of method if other than guideline:
- other: skin absorption study with human volunteer
Test material
- Reference substance name:
- N-isopropyl-N'-phenyl-p-phenylenediamine
- EC Number:
- 202-969-7
- EC Name:
- N-isopropyl-N'-phenyl-p-phenylenediamine
- Cas Number:
- 101-72-4
- Molecular formula:
- C15H18N2
- IUPAC Name:
- N1-phenyl-N4-(propan-2-yl)benzene-1,4-diamine
Constituent 1
Test animals
- Species:
- human
Results and discussion
Percutaneous absorptionopen allclose all
- Dose:
- 2g/10l
- Remarks on result:
- other: 90 min
- Remarks:
- No IPPD present in urine
- Dose:
- 2g/10l
- Remarks on result:
- other: 3 h
- Remarks:
- 100 µg/l IPPD in urine
- Dose:
- 2g/10l
- Remarks on result:
- other: 5 h
- Remarks:
- 350 µg/l IPPD in urine
- Dose:
- 2g/10l
- Remarks on result:
- other: 10.5 h
- Remarks:
- 570 µg/l IPPD in urine
Any other information on results incl. tables
After 105 h max. exctretion peak, the excretion began to drop, ahowing three consecutive slopes; excretion ceased 7 d after exposure.
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