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Toxicological information

Dermal absorption

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Administrative data

Endpoint:
dermal absorption in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: publication does not give sufficient experimental details

Data source

Reference
Reference Type:
publication
Title:
Excretion kinetics of the rubber anti-oxidant N-isopropyl-N'-phenyl-p-phenylenediamine
Author:
Scansetti G et al.
Year:
1987
Bibliographic source:
International Archives Occupational Environmental Health 59, 537-543

Materials and methods

Principles of method if other than guideline:
other: skin absorption study with human volunteer

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
human

Results and discussion

Percutaneous absorptionopen allclose all
Dose:
2g/10l
Remarks on result:
other: 90 min
Remarks:
No IPPD present in urine
Dose:
2g/10l
Remarks on result:
other: 3 h
Remarks:
100 µg/l IPPD in urine
Dose:
2g/10l
Remarks on result:
other: 5 h
Remarks:
350 µg/l IPPD in urine
Dose:
2g/10l
Remarks on result:
other: 10.5 h
Remarks:
570 µg/l IPPD in urine

Any other information on results incl. tables

After 105 h max. exctretion peak, the excretion began to drop, ahowing three consecutive slopes; excretion ceased 7 d after exposure.

Applicant's summary and conclusion