Registration Dossier

Diss Factsheets

Toxicological information

Dermal absorption

Currently viewing:

Administrative data

Endpoint:
dermal absorption in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: publication does not give sufficient experimental details

Data source

Reference
Reference Type:
publication
Title:
Excretion kinetics of the rubber anti-oxidant N-isopropyl-N'-phenyl-p-phenylenediamine
Author:
Scansetti G et al.
Year:
1987
Bibliographic source:
International Archives Occupational Environmental Health 59, 537-543

Materials and methods

Principles of method if other than guideline:
other: skin absorption study with human volunteer

Test material

Constituent 1
Chemical structure
Reference substance name:
N-isopropyl-N'-phenyl-p-phenylenediamine
EC Number:
202-969-7
EC Name:
N-isopropyl-N'-phenyl-p-phenylenediamine
Cas Number:
101-72-4
Molecular formula:
C15H18N2
IUPAC Name:
N1-phenyl-N4-(propan-2-yl)benzene-1,4-diamine

Test animals

Species:
human

Results and discussion

Percutaneous absorptionopen allclose all
Dose:
2g/10l
Remarks on result:
other: 90 min
Remarks:
No IPPD present in urine
Dose:
2g/10l
Remarks on result:
other: 3 h
Remarks:
100 µg/l IPPD in urine
Dose:
2g/10l
Remarks on result:
other: 5 h
Remarks:
350 µg/l IPPD in urine
Dose:
2g/10l
Remarks on result:
other: 10.5 h
Remarks:
570 µg/l IPPD in urine

Any other information on results incl. tables

After 105 h max. exctretion peak, the excretion began to drop, ahowing three consecutive slopes; excretion ceased 7 d after exposure.

Applicant's summary and conclusion