N-isopropyl-N'-phenyl-p-phenylenediamine

Repeated dose toxicity: inhalation

Administrative data

Endpoint:

short-term repeated dose toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: publication does not give sufficient experimental details

Data source

Reference

Reference Type:

publication

Title:

Comparative Toxicity of Mercaptobenzimidazole and N-phenyl-N-isopropylparaphenyleneamine

Author:

Vorob'eva RS et al.

Year:

1963

Bibliographic source:

Sov. Rubber Technol. 22, 11-12

Materials and methods

Test material

Test material information

Constituent 1

Reference substance name:

N-isopropyl-N'-phenyl-p-phenylenediamine

EC Number:

202-969-7

EC Name:

N-isopropyl-N'-phenyl-p-phenylenediamine

Cas Number:

101-72-4

Molecular formula:

C15H18N2

IUPAC Name:

N1-phenyl-N4-(propan-2-yl)benzene-1,4-diamine

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Administration / exposure

Route of administration:

inhalation

Duration of treatment / exposure:

15 d

Frequency of treatment:

2 h/d

Doses / concentrations

Remarks:

Doses / Concentrations:
300-400 mg/m3
Basis:

Control animals:

yes

Details on study design:

Post-exposure period: no data

Results and discussion

Target system / organ toxicity

Critical effects observed:

not specified

Any other information on results incl. tables

RS-Freetext:
bw gain unchanged, functional state of the nervous system
of some rats changed, malfunction of the liver, decreased
liver weight, kidney and heart weight unchanged, no morpho-
logical changes of the organs.