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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Description of key information

The acute toxicity of 4-Hydroxydiphenylamine the main hydrolysis product of IPPD to Daphnia magna was investigated in a static test according to EC No 440/2008, Method C.2 'Acute toxicity for Daphnia' (2008) which is equivalent to OECD Guideline for Testing of Chemicals No. 202 'Daphnia sp., Acute Immobilisation Test (adopted April 13, 2004). After 48 hours of exposure an EC50 of 0.69 mg/L (nominal) was determined (Currenta, 2010).
A second key study performed with the parent substance IPPD (Duslo 2007) resulted in an EC50 of 0.98 mg/L.

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
0.69 mg/L

Additional information

IPPD hydrolysis rapidly with a half- life of 3.9 hours under conditions relevant for the environment. In this case the REACH guidance document R7 allows the choice of performing the ecotox study either with the parent compound or with the hydrolysis product. In the current case studies for both, parent compound and hydrolysis product are available.