Registration Dossier
Registration Dossier
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EC number: 606-728-0 | CAS number: 212322-56-0
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 13 October 2017 - 06 December 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
Test material
- Reference substance name:
- ethyl 3-{1-[3-amino-4-(methylamino)phenyl]-N-(pyridin-2-yl)formamido}propanoate
- EC Number:
- 606-728-0
- Cas Number:
- 212322-56-0
- Molecular formula:
- C18 H22 N4 O3
- IUPAC Name:
- ethyl 3-{1-[3-amino-4-(methylamino)phenyl]-N-(pyridin-2-yl)formamido}propanoate
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- Ultra pure-grade water used for preliminary test and main test. The Agilent 1260 HPLC system was used. Ambient temperature for the preliminary test while temperature for man test was 20+/- 0.5 deg Celsius. Amount of test item was about five times saturation concentration determined in the preliminary test.
Results and discussion
Water solubility
- Water solubility:
- 1 653 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 6.44
Applicant's summary and conclusion
- Conclusions:
- Solubility of BIBR 1048 Diamine in ultra-pure water saturated with carbon dioxide at 20 +/- 0.5 °C is
1653 mg/L, determined pH 6.44.
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