2,5,7,10,11,14-hexaoxa-1,6-distibabicyclo[4.4.4]tetradecane

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2009-04-27 to 2009-07-21

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Remarks:

signed 2007-03-21

Type of method:

flask method

Water solubility:

>= 0.4 - <= 1.2 µg/L

Temp.:

20 °C

pH:

5.5

Details on results:

Under the conditions of this test (under exclusion of CO2 and O2 by argon atmosphere; flask method; loading 2g/L), the water solubility of diantimony tris(ethylene glycolate) at 20°C +/- 1°C could be determined between 0.4µ/L and 1.2µg/L (determined as dissolved Sb, separated by centrifugation from undissolved test item). Equlibrium was reached after 9 days stirring. The resulting pH value was approx. 5.5. Solubility is based on ICP-MS measurement of dissolved antimony. The test item was pulverized before the performance of the test.

ICP-MS analyses of the samples confirmed the low antimony concentration below 15µg/L. After 216, 240 and 264h the Sb concentrations were between 0.2 and 0.7µg/L. As a worst case scenario (larger surface) the date from the test with the pulverized test item diantimony tris(ethylene glycolate) were used. The mean values from the last three samplings (216 -264h) were constant with a difference below 15% between samplings (values of both test vessels were considered separately). Thus the mean value from each of these three samples was calculated as followes:

Test vessel I : 0.71 +/- 0.07 µg/L as Sb corresponds to 1.23 +/- 0.13µg/L as diantimony tris(ethylene glycolate); calculated for a theoretical Sb content of 57.5% (= factor 1.74)

Test vessel II : 0.22 +/- 0.01 µg/L as Sb corresponds to 0.38 +/- 0.02µg/L as diantimony tris(ethylene glycolate); calculated for a theoretical Sb content of 57.5% (= factor 1.74)

Conclusions:

Interpretation of results (migrated information): insoluble (< 0.1 mg/L)
The water solubility of diantimony tris(ethylene glycolate) at 20°C +/- 1°C could be determined between 0.4µ/L and 1.2µg/L . Equlibrium was reached after 9 days stirring. The resulting pH value was approx. 5.5

Description of key information

The water solubility of diantimony tris(ethylene glycolate) at 20°C +/- 1°C could be determined between 0.4µ/L and 1.2µg/L . Equilibrium was reached after 9 days stirring.

Key value for chemical safety assessment

Water solubility:

0.4 µg/L

at the temperature of:

20 °C

Additional information

Bio-accessibility data has also been generated, relevant to form read-across groups for systemic toxicological endpoints, as described in the relevant scientific opinions attached in Section 13.

 

(In CSR: Gastric bio-accessibility data has also been generated, relevant to form read-across groups for systemic toxicological endpoints, as described in the relevant scientific opinions included in the IUCLID file of the Registration Dossier)