Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 249-820-2 | CAS number: 29736-75-2
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The lowest valid NOEC for chronic toxicity to freshwater fish is 1.13 mg Sb/L for Pimephales promelas. (Kimball, 1978).
There are no valid chronic studies with marine fish.
Key value for chemical safety assessment
Additional information
Only two studies are considered to be valid (Kimball, 1978 and LeBlanc and Dean, 1984). However, only Kimball can be used to derive a PNEC since the NOECs reported by LeBlanc and Dean are unbounded.
LeBlanc and Dean (1984) exposed eggs from Pimephales promelas in a flow-through system, using two replicates, with five concentrations (range: 0.6 - 7.5 µg Sb/L) and two controls (one regular and one vehicle control (HCl)), with each replicate comprising 55 eggs. The tests were performed in well water with a hardness of 28-40 mg CaCO3/L. Since there were no statistically different effects (endpoints: mortality, larvae lengths and weights) when compared to the control, even at the highest concentration used (7.5 µg Sb/L), the resulting unbounded NOEC value was > 7.5 µg Sb/L.
A chronic test performed by Kimball (1978), used embryo-larvae of Pimephales promelas in a flow-through system, with four replicates and six concentrations (range: 0.52 – 19.11 mg Sb/L) and a control, with each group comprising 20 eggs. The tests were performed with hard well water. The lowest resulting NOEC from this study, using reduction of length as an indicator of toxicity, is 1.13 mg Sb/L. This value is also the lowest valid NOEC for freshwater fish from long-term toxicity tests.
There are studies by Birge and co-workers (Birge, 1978; Birge et al., 1980), which report NOECs below 1.13 mg Sb/l. However, even though these studies are well performed, with measured test concentrations etc., neither of them are considered to be valid. The reason for this is that the test concentrations used are never reported, which makes it impossible to determine whether the calculated NOEC values are included in the tested concentration range.
The reasons why the result by Doe et al.(1987) on Oncorhynchus mykiss is not considered reliable are presented in the section on acute toxicity above.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
