1H-Imidazole-1-ethanol, 4,5-dihydro-, 2-C7-17-alkyl derivs.

Short-term toxicity to fish

Administrative data

Endpoint:

short-term toxicity to fish

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Analytical monitoring is missing; deviation in test: temperature of test water lower as required by species.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2001

Report date:

2001

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 203 (Fish, Acute Toxicity Test)

Deviations:

yes

Remarks:

Analytical monitoring is missing; temperature of test water lower as required by species

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

(Z)-2-(8-heptadecenyl)-4,5-dihydro-1H-imidazole-1-ethanol

EC Number:

244-501-4

EC Name:

(Z)-2-(8-heptadecenyl)-4,5-dihydro-1H-imidazole-1-ethanol

Cas Number:

21652-27-7

IUPAC Name:

2-(2-heptadec-8-en-1-yl-4,5-dihydro-1H-imidazol-1-yl)ethanol

Sampling and analysis

Analytical monitoring:

no

Test solutions

Vehicle:

no

Test organisms

Test organisms (species):

Danio rerio (previous name: Brachydanio rerio)

Study design

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

96 h

Test conditions

Hardness:

2.466 mmol/L

Test temperature:

20 °C +/- 1 °C

pH:

7.91-8.10 (initial)
8.01-8.21 (end of test)

Dissolved oxygen:

75.2-85.8 % saturation (initial)
89.5-91.5 % saturation (end of test)

Nominal and measured concentrations:

Nominal concentrations: 0.0625, 0.125, 0.25, 0.5, 1.0 mg/L
No measured concentrations available

Reference substance (positive control):

no

Results and discussion

Effect concentrations

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

0.35 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Conclusions:

A LC50 of 0.35 mg/L was determined when Danio rerio was exposed to (Z)-2-(8-Heptadecenyl)-4,5-dihydro-1H-imidazole-1-ethanol for 96 hours.

Executive summary:

An acute acute fish toxicity test according to OECD Guideline 203 was carried out with (Z)-2-(8-Heptadecenyl)-4,5-dihydro-1H-imidazole-1-ethanol in zebra fish (danio rerio). A LC50 of 0.35 mg/L was determined.