Registration Dossier
Registration Dossier
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EC number: 202-436-9 | CAS number: 95-63-6
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 0.12 mg/L
- Assessment factor:
- 1
- Extrapolation method:
- sensitivity distribution
- PNEC freshwater (intermittent releases):
- 0.12 mg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0.12 mg/L
- Assessment factor:
- 1
- Extrapolation method:
- sensitivity distribution
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 2.41 mg/L
- Assessment factor:
- 1
- Extrapolation method:
- sensitivity distribution
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 13.56 mg/kg sediment dw
- Assessment factor:
- 1
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 13.56 mg/kg sediment dw
- Assessment factor:
- 1
- Extrapolation method:
- equilibrium partitioning method
Hazard for air
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 2.34 mg/kg soil dw
- Assessment factor:
- 1
- Extrapolation method:
- equilibrium partitioning method
Hazard for predators
Additional information
PNECs were derived for freshwater, saltwater, sediment, soil and micro-organisms using the HC5 model plus statistical extrapolation or equilibrium partitioning calculations.
Conclusion on classification
The available data for 1,2,4-trimethylbenzene indicate the acute aquatic toxicity ranges from 2.356 mg/L (96hr EC50 for Algae - QSAR) to 7.72 mg/L (96hr LC50 for fish - measured) and the log Kow is 3.63 (i.e. < 4.0). The substance does not meet the criteria for ready biodegradability but degrades rapidly and is therefore considered not to be persistent in the environment.
Under the harmonization of Annex 1 of Directive 67/548/EEC, 1,2,4-trimethylbenzene has been classified as N R51-53 which has been transferred to a classification of Aquatic Chronic 2 hazard to the environment and the hazard statement 'Toxic to aquatic life with long lasting effects' under the GHS.
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