Registration Dossier

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Administrative data

Hazard for aquatic organisms

Freshwater

Hazard assessment conclusion:
PNEC aqua (freshwater)
PNEC value:
0.12 mg/L
Assessment factor:
1
Extrapolation method:
sensitivity distribution
PNEC freshwater (intermittent releases):
0.12 mg/L

Marine water

Hazard assessment conclusion:
PNEC aqua (marine water)
PNEC value:
0.12 mg/L
Assessment factor:
1
Extrapolation method:
sensitivity distribution

STP

Hazard assessment conclusion:
PNEC STP
PNEC value:
2.41 mg/L
Assessment factor:
1
Extrapolation method:
sensitivity distribution

Sediment (freshwater)

Hazard assessment conclusion:
PNEC sediment (freshwater)
PNEC value:
13.56 mg/kg sediment dw
Assessment factor:
1
Extrapolation method:
equilibrium partitioning method

Sediment (marine water)

Hazard assessment conclusion:
PNEC sediment (marine water)
PNEC value:
13.56 mg/kg sediment dw
Assessment factor:
1
Extrapolation method:
equilibrium partitioning method

Hazard for air

Hazard for terrestrial organisms

Soil

Hazard assessment conclusion:
PNEC soil
PNEC value:
2.34 mg/kg soil dw
Assessment factor:
1
Extrapolation method:
equilibrium partitioning method

Hazard for predators

Additional information

PNECs were derived for freshwater, saltwater, sediment, soil and micro-organisms using the HC5 model plus statistical extrapolation or equilibrium partitioning calculations.

Conclusion on classification

The available data for 1,2,4-trimethylbenzene indicate the acute aquatic toxicity ranges from 2.356 mg/L (96hr EC50 for Algae - QSAR) to 7.72 mg/L (96hr LC50 for fish - measured) and the log Kow is 3.63 (i.e. < 4.0). The substance does not meet the criteria for ready biodegradability but degrades rapidly and is therefore considered not to be persistent in the environment.

Under the harmonization of Annex 1 of Directive 67/548/EEC, 1,2,4-trimethylbenzene has been classified as N R51-53 which has been transferred to a classification of Aquatic Chronic 2 hazard to the environment and the hazard statement 'Toxic to aquatic life with long lasting effects' under the GHS.