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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

Description of key information

The  48 hour LC50 for Daphnia magna was experimentally determined to be 3.6 mg/l (Bobra et al, 1983).

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
3.6 mg/L

Additional information

Based on the information available the Bobra et al, 1983 study is considered to be the key study. The study has a reliability rating of 2 because it is a non-GLP; non-guideline study, published in peer reviewed literature with minor restrictions in design and/or reporting but otherwise adequate for assessment. There is otherwise no information in the article to suggest that the data are invalid. The result does not indicate that 1,2,4-trimethylbenzene would meet the criteria for toxic in the PBT assessment. This endpoint would not affect the classification of the 1, 2, 4-trimethylbenzene since the substance is biodegradable and the log Kow is < 4.0.

A supporting study by Abernathy et al, 1986 reports a 24 hr LC50 for Artemia of 12.0 mg/l. A QSAR calculation using the ECOSAR model gives an estimated 48 hr LC50 for Daphnids of 2.4 mg/l.