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EC number: 700-149-8 | CAS number: -
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 11.57 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 75
- Modified dose descriptor starting point:
- NOAEC
Acute/short term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
Acute/short term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 33.3 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 300
- Modified dose descriptor starting point:
- NOAEL
Acute/short term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
Acute/short term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
Workers - Hazard for the eyes
Additional information - workers
Generally the toxicity of FAT 40841/A TE is very low. No mortality was seen in acute toxicity studies in rats (oral and dermal) and the NOAEL in the subacute oral study in rats was >= 1000 mg/kg bw. In a developmental toxicity/teratogenicity study according to OECD 414 no major toxicological findings in females and fetuses were noted.
FAT 40841/A TE is classified to have irreversible effects to the eye. As no dose-response data is available from the respective study (OECD 405) a DNEL cannot be derived.
The test item is a skin sensitizer. As at all tested doses the EC3 is surpassed by at least a factor of 1.5 and as an inverse dose-response was found, a quantitative derivation of a DNEL based on this endpoint is not possible.
Accordingly suitable risk management measures to protect from exposure to the eyes and the skin should be implemented.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 2.89 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 150
- Modified dose descriptor starting point:
- NOAEC
Acute/short term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
Acute/short term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 16.7 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
Acute/short term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
Acute/short term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.67 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
Acute/short term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
DNEL related information
General Population - Hazard for the eyes
Additional information - General Population
Generally the toxicity of FAT 40841/A TE is very low. No mortality was seen in acute toxicity studies in rats (oral and dermal) and the NOAEL in the subacute oral study in rats was >= 1000 mg/kg bw. In a developmental toxicity/teratogenicity study according to OECD 414 no major toxicological findings in females and fetuses were noted.
FAT 40841/A TE is classified to have irreversible effects to the eye. As no dose-response data is available from the respective study (OECD 405) a DNEL cannot be derived.
The test item is a skin sensitizer. As at all tested doses the EC3 is surpassed by at least a factor of 1.5 and as an inverse dose-response was found, a quantitative derivation of a DNEL based on this endpoint is not possible.
Accordingly suitable risk management measures to protect from exposure to the eyes and the skin should be implemented.
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