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EC number: 293-026-9 | CAS number: 91050-80-5
Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
Description of key information
NOEC (56 d) = 250 mg/kg soil dw for Eisenia fetida (OECD 222); read across
Key value for chemical safety assessment
Additional information
No experimental data evaluating the toxicity of of Fatty acids, C16-18, tetraesters with 3,3'-oxybis[1,2-propanediol] (CAS 91050-80-5)to soil macroorganisms are available. Therefore, data from a structurally related analogue substance, 1,2,3 -propanetriol, homopolymer, diisooctadecanoate (CAS 63705-03-3), is used as read-across in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. Both substances are fatty esters consisting on mono-, di- and triglycerol and similar fatty acid chain length (target substance: C16-C18; source substance: C18iso).The water solubilities (target substance: < 0.05 mg/L; source substance: < 0.15 mg/L) and log Kow values (log Kow > 4) of both substances are comparable. The log Kow of these substances indicate adsorption potential to soil. Therefore, 1,2,3 -propanetriol, homopolymer, diisooctadecanoate can be used as read across substance in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5.
The experimental study investigating the toxicity of the source substance 1,2,3 -propanetriol, homopolymer, diisooctadecanoate to soil macroorganism was conducted according to OECD 222 under GLP conditions (Moser & Scheffczyk, 2013). Eisenia fetida was exposed to five nominal concentration between 62.5 and 1000 mg test item/ kg soil dw for 56 d. Significant effects on reproduction were observed at the two highest test cocnentrations resulting in a NOEC (56 d) of 250 mg/kg soil dw.
Based on the results obtained for the structurally analogue substance (in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5), it can be concluded that Fatty acids, C16-18, tetraesters with 3,3'-oxybis[1,2-propanediol] (CAS 91050-80-5) will show a similar toxicity profile to soil macroorganisms.
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