Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 237-741-6 | CAS number: 13963-57-0
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Guideline:
- other: read across (grouping: skin irritation inclusion rules by BfR-ketones)
- GLP compliance:
- no
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Score:
- 1.73
- Max. score:
- 8
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Classification Xi;R38 (DSD) respectively Skin irritant cateory 2 with H315 (CLP)
Reference
See attached OECD Toolbox v2.0 study for skin irritation/corrosion.
Note that v3.1 gave identical results.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation
- Remarks:
- other: read across
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Guideline:
- other: read across (grouping: skin irritation inclusion rules by BfR-ketones)
- GLP compliance:
- no
- Irritation parameter:
- other: Modified maximum average score
- Basis:
- mean
- Score:
- 30.4
- Max. score:
- 110
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Classification Xi;R36 (DSD), respectively Eye irritant category 2 with H319
Reference
See attached OECD Toolbox v2.0 study for eye irritation/corrosion.
Note that v3.1 gave identical results.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Effects on eye irritation: irritating
Justification for classification or non-classification
Based on the results found this substance must be classified as:
Skin irritant category 2 with H315 (causes skin irritation)
Eye irritant category 2 with H319 (causes serious eye irritation)
STOT SE category 3 for inhalation with H335 (may cause respiratory irritation)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
