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Toxicological information

Specific investigations: other studies

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Administrative data

Endpoint:
endocrine system modulation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2013
Report Date:
2013

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: according to P. Sohoni and J.P. Sumpter (1998)
Principles of method if other than guideline:
The yeast cells used in the yeast androgen screening (YAS) assay have been stably transformed with genes for the human androgen receptor and the ß-galactosidase reporter gene. Androgenic as well as antiandrogenic potentials of the test substances mediated by receptor binding or blocking can be determined using this assay, respectively.
GLP compliance:
no
Type of method:
in vitro

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material: C9Aldoxim
- Physical state: Liquid, greenyellow, clear
- Analytical purity: >90%
- Storage condition of test material: Room temperature

Test animals

Species:
other: yeast

Administration / exposure

Vehicle:
DMSO

Results and discussion

Details on results:
In this study, the test substance C9 Aldoxim showed no androgenic activity in comparison to dihydrotestosterone.
In this study, the test substance C9 Aldoxim showed clear antiandrogenic activity from about 10-6 mol/L onward in comparison to hydroxyflutamide.
No cytotoxicity was observed.

Applicant's summary and conclusion