Registration Dossier
Registration Dossier
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EC number: 250-575-9 | CAS number: 31335-74-7
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
NOEC (21d) ≥ 0.0019 mg/L for Daphnia magna (OECD 211); read-across
Key value for chemical safety assessment
Additional information
No studies are available on the toxicity of 2,2-dimethyl-1,3-propanediyl dioctanoate (CAS No. 31335-74-7) to aquatic invertebrates. Therefore, a read-across to the structurally most similar category member Heptanoic acid, ester with 2,2-dimethyl-1,3-propanediol (CAS No. 68855-18-5) was conducted. This read across approach is in accordance with Regulation (EC) No 1907/2006, Annex XI, 1.5. Grouping of substance and read across approach. Further justification is given within the endpoint summary 6.1 and within the category justification in Section 13.
The key study conducted with Heptanoic acid, ester with 2,2-dimethyl-1,3-propanediol (CAS No. 68855-18-5) was performed according to OECD Guideline 211 and GLP, in a semi-static system (Parr, 2013). During 21 days, the test organism Daphnia magna was exposed to five test concentrations up to 0.0019 mg/L measured (TWA). No significant effects on reproduction were observed during the study and the NOEC (21d) was reported to be ≥ 0.0019 mg/L.
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