Registration Dossier
Registration Dossier
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EC number: 206-532-1 | CAS number: 353-42-4
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well-documented, non-guideline and non-GLP study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 965
- Report date:
- 1965
Materials and methods
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
Test material
- Reference substance name:
- Dimethyl ether-boron trifluoride
- EC Number:
- 206-532-1
- EC Name:
- Dimethyl ether-boron trifluoride
- Cas Number:
- 353-42-4
- Molecular formula:
- C2H6BF3O
- IUPAC Name:
- (dimethyloxo)trifluoro-λ⁵-borane
- Details on test material:
- - Name of test material (as cited in study report): Vorfluorid-Methylaetherat
- Physical state: liquid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Vienna White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated eye of the same animal
- Amount / concentration applied:
- 50 ul
- Duration of treatment / exposure:
- 24 h
- Observation period (in vivo):
- 8 days
- Number of animals or in vitro replicates:
- 2
Results and discussion
Any other information on results incl. tables
Results:
| 1 hour | 24 hours | 8 days | |
| undiluted test substance | O +++ | N++; O+++ | N++; strong ulceration |
O = Opacity
N = Necrosis
++ = strong
+++ = very strong
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye)
- Remarks:
- Migrated information
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