Registration Dossier
Registration Dossier
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EC number: 203-157-5 | CAS number: 103-90-2
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The inhibition growth concentration (IGC50) value of Paracetamol in microorganism (Tetrahymena pyriformis) in a 46 hr study on the basis of growth inhibition effect was estimated to be 189.00 mg/L.
Key value for chemical safety assessment
Additional information
Based on the study conducted using the prediction model of DEPA, the inhibition growth concentration (IGC50) in microorganism (Tetrahymena pyriformis) in a 46 hr study on the basis of growth inhibition effect was estimated to be 189.00 mg/L.
Also data from Koch, H. P. et al (1993),the inhibition concentration (IC50) in Saccharomyces cerevisiae was found to be 92 mg/L.
In another study conducted by Rhone Poulenc Chimie Courbevoie Cedex,the effective concentration (EC0) in microorganism (anaerobic bacteria from a domestic water treatment plant) in a 24 hr study by Fermentation tube method was found to be 2000 mg/L.
Thus from the above studies available for the the target substance Paracetamol, the IGC50 and IC50 values for microorganism is ranging from 92 - 189 mg/L for various effects also EC0 was reported as 2000 mg/L.
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