Registration Dossier
Registration Dossier
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EC number: 201-947-4 | CAS number: 89-87-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1986-03-10 to 1986-04-21
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according to previous OECD TG.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 4-nitro-m-xylene
- EC Number:
- 201-947-4
- EC Name:
- 4-nitro-m-xylene
- Cas Number:
- 89-87-2
- Molecular formula:
- C8H9NO2
- IUPAC Name:
- 2,4-dimethyl-1-nitrobenzene
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: sesame oil
- Doses:
- 1600 mg/kg body weight, 2000 mg/kg body weight, 2500 mg/kg body weight, 3150 mg/kg body weight
- No. of animals per sex per dose:
- 5 male and 5 female rats per dose
- Control animals:
- no
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 690 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 1 270 - 2 030
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2 240 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 1 840 - 2 730
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of the present study 4-nitro-m-xylene is harmful (Xn, R22) according to 83/467/EEC and Acute Tox. Cat. 4 (H302) according to 1272/2008/EC.
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