Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-436-4 | CAS number: 120-93-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 958
- Report date:
- 1958
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- The substance was applied (90% in water) in the form of a paste for 1, 5, 15 minutes or 20 hours to the rabbit skin on the back.
- GLP compliance:
- no
- Remarks:
- pre-GLP
Test material
- Reference substance name:
- 2-imidazolidone
- EC Number:
- 204-436-4
- EC Name:
- 2-imidazolidone
- Cas Number:
- 120-93-4
- Molecular formula:
- C3H6N2O
- IUPAC Name:
- 2-imidazolidone
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- water
- Controls:
- other: untreated skin of same animal
- Amount / concentration applied:
- 90% in water in the form of a paste (amount not specified)
- Duration of treatment / exposure:
- 1 minute, 5 minutes, 15 minutes and 20 hours
- Observation period:
- 8 days
- Number of animals:
- 5 in total; substance has been applied on the skin of the back of all 5 animals
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing: concentrated Lutrol and 50% lutrol
- Time after start of exposure: see duration of exposure; 1 minute, 5 minutes, 15 minutes and 20 hours
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- edema score
- Remarks:
- (1, 5 and 15 minutes of exposure)
- Basis:
- mean
- Time point:
- other: 24 hours and 8 days
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Remarks:
- (1, 5 and 15 minutes of exposure)
- Basis:
- mean
- Time point:
- other: 24 hours and 8 days
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- other: observations regarding skin irritation in case of 20 hours exposure
- Basis:
- mean
- Remarks on result:
- other: Slight erythema with individual hemorrhages at 24 hours. Circumscribed crusts (lentil-sized); fallen off at 8 days.
- Irritant / corrosive response data:
- The application for 1, 5 or 15 minutes on the back led to no findings within 8 days. After application for 20 hours, on the back, slight erythema was recorded with individual hemorrhages at 24 hours. Circumscribed crusts (lentil-sized; fallen off) were recorded at day 8 of the observation period.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
