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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1958
Report date:
1958

Materials and methods

Principles of method if other than guideline:
Up to 5010 mg/kg of the substance in an aqueous solution of max 10%, has been administered intraperitoneal in mice.
GLP compliance:
no
Remarks:
pre-GLP
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
2-imidazolidone
EC Number:
204-436-4
EC Name:
2-imidazolidone
Cas Number:
120-93-4
Molecular formula:
C3H6N2O
IUPAC Name:
2-imidazolidone
Test material form:
solid

Test animals

Species:
mouse

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
water
Remarks:
distilled
Details on exposure:
1-10% aqueous solution.
Doses:
20, 79, 316, 1260 and 5010 mg/kg
No. of animals per sex per dose:
5010 mg/kg-10 animals, lower doses-2 animals
Control animals:
no
Details on study design:
- Duration of observation period following administration: 7 days
- Frequency of observations and weighing: after 1 hour, 24 hours, 48 hours, 3 days and 7 days
- Necropsy of survivors performed: yes on 5 animals
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other:

Results and discussion

Effect levels
Key result
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Mortality:
No mortality was observed.
Clinical signs:
Animals dosed up to 1260 mg/kg did not show any specific signs, animals dosed with 5010 mg/kg showed after 5 hours accelerated breathing, after 8 hours besides accelerated breathing also sticky skin. The next morning only the sticky skin remained.
Body weight:
regular
Gross pathology:
regular

Applicant's summary and conclusion

Conclusions:
LD50 > 51010 mg/kg