Registration Dossier
Registration Dossier
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EC number: 416-740-6 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Acute Toxicity Oral, 1 key study- LD50 >2000 mg/kg for rat (similar to OECD TG 401, GLP)
Acute Toxicity Inhalation-Testing not required based on Column 2 Annex VIII
Acute Toxicity Dermal, 1 key study-LD50 >2000 mg/kg in rabbits (similar to OECD TG 402, GLP)
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Additional information
There are limited but adequate data for the assessment of the acute toxicity of the submission substance. All animal studies were performed on the submission substance in a manner similar or equivalent to currently established OECD test guidelines. The submission substance has a low order of toxicity via ingestion where the LD50in rats is >2000mg/kg and via dermal exposure where the LD50in rabbits is >2000mg/kg. It is not required to dose via the inhalation route since exposure via inhalation is unlikely taking into account the physical chemical properties of the substance. Based on these data, the acute toxicity of the submission substance is expected to be low.
Justification for classification or non-classification
The submission substance has a low order of acute toxicity where the LD50 via ingestion is > 2000mg/kg and the LD50 via dermal exposure is >2000 mg/kg. Based on these data, classification is not warranted under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP) or under the Directive 67/518/EEC for dangerous substances and Directive 1999/45/EC for preparations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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