Registration Dossier
Registration Dossier
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EC number: 203-802-0 | CAS number: 110-77-0
Endpoint summary
Administrative data
Description of key information
The key skin irritation study (Chevron Phillips Chemical Company, 2010) was an in vitro study conducted using EPISKIN (a human epidermis skin construct) with GLP and in a manner similar to OECD 439 (that was adopted after the publication of this study). This study reported that the test material was unlikely to be irritant to the skin.
The key eye irritation study (Chevron Phillips Chemical Company, 2010) was an in vitro study conducted using bovine corneas according to OECD 437 and with GLP. This test is limited to an evaluation of corrosion or severe irritation. The In Vitro Irritancy Score determined indicated that the test material was likely to cause corrosion or severe irritation to the eye.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Only one skin irritation study was available for evaluation. This in vitro study was comparable to a guideline study (OECD 439; reliability 1; with GLP). The methodology used, the EPISKIN Skin Irritation Test (42 hours), has been validated by the European Centre for the Validation of Alternative Methods and since the publication of this study OECD guideline 439 has been adopted (July 2010).
Only one eye irritation study was available for evaluation. This in vitro study was a guideline study (reliability 1; with GLP). The study is recommended for use as part of a tiered-testing strategy.
Effects on eye irritation: corrosive
Justification for classification or non-classification
The available data support the classification: Category 1 (irreversible effects to the eye).
The available data do not support classification for irritation to the skin.
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