Registration Dossier
Registration Dossier
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EC number: 455-040-5 | CAS number: 3789-59-1
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
The substance (S)-1-phenylpropylamine (CAS 3789-59-1) was tested for its sensitizing effect on the skin of the local lymph node assay based on the OECD method 429 (skin sensitization). The results of this assay indicate that the test article, at the concentrations tested, did not induce a hypersensitivity response according to the criteria used for a positive response. [Calvert Preclinical Services, 2001]
Migrated from Short description of key information:
Guinea pig (OECD 429): not sensitizing (Smith Kline, 2001)
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
- Migrated from Short description of key information:
Currently, there is no information available.
Justification for classification or non-classification
Based on the test result of the Local Lymph node Assay and applying the criteria of Annex VI/II D of the Council Directive of July 29, 1983 for the 5th Amendment of the Directive 67/548 EEC (= 83/467 EEC)) for test evaluation, the test substance does not fulfill the criteria of being a skin sensitizer and therefore need not to be classified according to EU or GHS criteria. There is no information given that (S)-1-phenylpropylamine is a sensitizer of the respiratory tract.
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