Registration Dossier
Registration Dossier
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EC number: 455-040-5 | CAS number: 3789-59-1
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 14.01.-15.09.2000
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well documented in vitro study report which meets basic scientific principles
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- enucleated eye test
- GLP compliance:
- yes
Test material
- Details on test material:
- - Name of test material: (S)1-Phenylpropylamin (CAS 3789-59-1)
Constituent 1
Test animals / tissue source
- Species:
- rabbit
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
Results and discussion
In vivo
Results
- Irritation parameter:
- other: corneal swelling [%]
- Basis:
- mean
- Time point:
- other: 240 min
- Score:
- 98.2
Applicant's summary and conclusion
- Conclusions:
- Following assessment of the data for all endpoints, the test material was considered to have the potential to cause ocular irritancy in vivo.
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