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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Guideline study with acceptabele restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1991
Report date:
1991

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-(2-hydroxyethoxy)propyl prop-2-enoate; 2-[2-[2-[2-(1-methyl-2-prop-2-enoyloxy-ethoxy)ethoxymethyl]butoxy]ethoxy]propyl 3-(dibutylamino)propanoate
EC Number:
605-658-8
Cas Number:
173011-06-8
Molecular formula:
Not specified UVCB - Reaction product of ethoxylated/propoxylated (0-6 EO; 0-6 PO) propylidenetrimethanol with acrylic acid and dibutylamine (acrylic acid : dibutylamine = 3:1)
IUPAC Name:
2-(2-hydroxyethoxy)propyl prop-2-enoate; 2-[2-[2-[2-(1-methyl-2-prop-2-enoyloxy-ethoxy)ethoxymethyl]butoxy]ethoxy]propyl 3-(dibutylamino)propanoate
Details on test material:
- Name of test material (as cited in study report): Laromer LR 8864
- Physical state: liquid, colorless
- Analytical purity: 100 %
- Lot/batch No.: R /395

Test animals

Species:
rabbit
Strain:
Vienna White
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Gaukler, FRG
- Weight at study initiation: male: 2.78 kg; female: 2.66 kg
- Housing: 1 animal per cage
- Diet (e.g. ad libitum): Kliba 341, 130 g per animalper day
- Water (e.g. ad libitum): 250 ml tap water per animal per day


ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 24
- Humidity (%): 30 - 70
- Photoperiod (hrs dark / hrs light): 12/12

Test system

Type of coverage:
semiocclusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Controls:
other: untreated skin sites of the same animal
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml
Duration of treatment / exposure:
4 h
Observation period:
72 h
Number of animals:
male. 2
female: 1
Details on study design:
TEST SITE
- Area of exposure: 2.5 x 2.5 cm
- Type of wrap if used: four layers of absorbent gauze + porous bandage

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
edema score
Remarks:
24 - 48- 72h
Basis:
mean
Time point:
other: 24 - 48- 72h
Score:
0
Max. score:
0
Reversibility:
fully reversible within: 72 h
Irritation parameter:
erythema score
Remarks:
24 - 48- 72h
Basis:
mean
Time point:
other: 24 - 48- 72h
Score:
0.3
Max. score:
1
Reversibility:
fully reversible within: 72h

Any other information on results incl. tables

Readings:

Time

Animal No.

Erythema

Edema

4h

1

0

0

2

0

0

3

1

0

24h

1

1

0

2

0

0

3

1

0

48h

1

1

0

2

0

0

3

0

0

72h

1

0

0

2

0

0

3

0

0

Mean

 

0.3

0

 

 

Applicant's summary and conclusion