Registration Dossier

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1991
Report date:
1991

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-(2-hydroxyethoxy)propyl prop-2-enoate; 2-[2-[2-[2-(1-methyl-2-prop-2-enoyloxy-ethoxy)ethoxymethyl]butoxy]ethoxy]propyl 3-(dibutylamino)propanoate
EC Number:
605-658-8
Cas Number:
173011-06-8
Molecular formula:
Not specified UVCB - Reaction product of ethoxylated/propoxylated (0-6 EO; 0-6 PO) propylidenetrimethanol with acrylic acid and dibutylamine (acrylic acid : dibutylamine = 3:1)
IUPAC Name:
2-(2-hydroxyethoxy)propyl prop-2-enoate; 2-[2-[2-[2-(1-methyl-2-prop-2-enoyloxy-ethoxy)ethoxymethyl]butoxy]ethoxy]propyl 3-(dibutylamino)propanoate
Details on test material:
- Name of test material (as cited in study report): Laromer LR 8664
- Physical state: liquid, colorless
- Analytical purity: 100%
- Lot/batch No.: R 7/395


Test animals / tissue source

Species:
rabbit
Strain:
Vienna White
Details on test animals or tissues and environmental conditions:
TEST ANIMALS
- Source: Gaukler, Offenbach, FRG
- Housing: single
- Diet (e.g. ad libitum): Kliba 241, 4MM; about 130 g per animal/per day
- Water (e.g. ad libitum): 250 ml tap water per animal/per day
- Acclimation period: 8 days

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 24
- Humidity (%): 30 - 70
- Photoperiod (hrs dark / hrs light): 12/12

Test system

Vehicle:
unchanged (no vehicle)
Controls:
other: untreated eye
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 ml


Number of animals or in vitro replicates:
1 male, 2 female

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
other: 24 - 48 - 72 h
Score:
0
Max. score:
0
Irritation parameter:
iris score
Basis:
mean
Time point:
other: 24 - 48 - 72 h
Score:
0
Max. score:
0
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
other: 24 - 48 - 72 h
Score:
0.3
Max. score:
1
Irritation parameter:
chemosis score
Basis:
mean
Time point:
other: 24 - 48 - 72 h
Score:
0
Max. score:
0

Any other information on results incl. tables

Results Acute Eye irritation

Readings

Animals

Cornea

Iris

Conjunctiva

OP

AR

RED

SW

DI

1 H

1

0

0

0

2

0

2

2

0

0

0

2

0

2

3

0

0

0

2

0

2

24 H

1

0

0

0

0

0

0

2

0

0

0

1

0

0

3

0

0

0

0

0

0

48 H

1

0

0

0

0

0

0

2

0

0

0

0

0

0

3

0

0

0

0

0

0

72 H

1

0

0

0

0

0

0

2

0

0

0

0

0

0

3

0

0

0

0

0

0

ME

1

0.0

 

0.0

0.0

0.0

 

2

0.0

 

0.0

0.3

0.0

 

3

0.0

 

0.0

0.0

0.0

 

ME

 

0.0

 

0.0

0.1

0.0

 

Applicant's summary and conclusion