Registration Dossier
Registration Dossier
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EC number: 911-694-8 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Additional information
Based on the results obtained from acetals, formaldehyde detection and ethanol detection, it can be stated that glycerol formal and other investigated acetals half-life at pH4, 7 and 9 and 25°C > 1 year. Those results are confirmed by a Klimisch code 4 study saying that no hydrolysis of GF to formaldehyde was observed after 7 days of incubation in a buffer at 37°C. The pKa of the substance corroborates those data.
Glycerol formal showed no signs of biodegradation under test conditions.
Based on the results of the documented QSAR predictions for each isomer, publicly available data, and the professional judgment of Molcode experts, the following conclusions were made.
It is considered that since the two isomeric compounds have been predicted to possess rather similar degradation/persistence properties, the particular composition of the mixtures within the range of the commonly commercially available ratio has virtually no effect on the overall persistence of the mixture. Therefore, the persistence: biotic degradation in water as the half-life value of glycerol formal is considered to be T(0.5) 200 h, corresponding to “not persistent” or “low persistence” depending on the scale used.
Following point 9.2.1.3 of the REACH reglementation, the adsorption potential of glycerol formal is very low (0<Koc<50, McCall & Helling's classification, very high mobility class). So no adsorption of GF is expected in the soil, therefore no bioaccumulation will occur as it will be transported away.
No risk of bioaccumulation. Log BCF: 0.5
In the ECHA guidance document R7a, chapter R.7.1.15.3 send to the equations presented in the EU TGD on Risk assessment chapter 4.3.4. There the equation for Nonhydrophobics was used and the Koc calculated. Koc for glycerol formal was found to be 3.2.
Koc of 1,3-dioxan-5-ol and 1,3-dioxolane-4-methanol (glycerol formal ingredients) was estimated from log Kow with KOCWIN v2.00 as 0.3852 and 1.137 L/kg, respectively. With Koc value <15 l/kg, both glycerol formal ingredients are considered very mobile in soil.
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