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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Adequacy of study:
other information

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: 92/69/EWG, B.3
GLP compliance:
yes
Limit test:
no

Test animals

Species:
other: rat, Wistar Hsd Cpb:WU

Administration / exposure

Type of coverage:
occlusive
Duration of exposure:
24 h

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
< 2 000 mg/kg bw
Mortality:
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 5
Male: 400 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 5
Female: 400 mg/kg bw; Number of animals: 5; Number of deaths: 0
Clinical signs:
other: Signs of toxicity related to dose levels: 2000 mg/kg bw.; black discoloration of the treatment-site, piloerection, decreased motility, temporary vocalization. 400 mg/kg bw.; 2 d - 22 d partial induration, swelling, skin detachment and weeping,
Gross pathology:
Effects on organs:
2000 mg/kg:

The gross pathology investigations revealed no other
findings than detected at the treatment area. The following
changes were seen: black discoloration of the skin at the
treatment area.


400 mg/kg:

The following changes at the treatment area were not
completely healed at final necropsy: partial induration,
skin detachment and weeping, black discoloration of the
skin. No other findings were detected at this necropsy.
Other findings:
Signs of toxicity (local):
2000 mg/kg bw.; 2 h - 2 d

spasmodic state and increased salivation.

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU