Registration Dossier
Registration Dossier
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EC number: 215-137-3 | CAS number: 1305-62-0
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- sub-chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only secondary literature.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Alkaline materials
- Author:
- Pierce JO
- Year:
- 1 993
- Bibliographic source:
- Clayton GD, Clayton FE. eds.; Patty's Industrial Hygiene and Toxicology, 4th ed., Vol. 2a, NY: John Wiley, 762-765, 1993
- Reference Type:
- secondary source
- Title:
- Alkaline materials
- Author:
- Pierce JO
- Year:
- 1 993
- Bibliographic source:
- cited in: Consensus Report for Calcium Oxide and Calcium Hydroxide, February 24, 1999
Materials and methods
- Principles of method if other than guideline:
- Method: no data
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Calcium dihydroxide
- EC Number:
- 215-137-3
- EC Name:
- Calcium dihydroxide
- Cas Number:
- 1305-62-0
- Molecular formula:
- CaH2O2
- IUPAC Name:
- calcium dihydroxide
- Details on test material:
- - Name of test material (as cited in study report): calcium hydroxide
- Analytical purity: no data given
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: drinking water
- Vehicle:
- water
- Duration of treatment / exposure:
- three months
- Frequency of treatment:
- daily via drinking water
Doses / concentrations
- Remarks:
- Doses / Concentrations:
50, 350 mg/L
Basis:
nominal in water
- No. of animals per sex per dose:
- no data given
- Control animals:
- not specified
Results and discussion
Results of examinations
- Details on results:
- According to the authors, after two months of treatment the animals became restless and aggressive, food intake was lower. After three months the animals had lost weight and showed lower hemoglobin values and lower counts of red and white blood cells. Examinations at necropsy revealed inflammation and damage in the stomach, small intestine, kidneys and liver. No further informations given, no differentiation of the effects seen at the two doses investigated.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
