2-[2-(3-aminopropoxy)ethoxy]ethanol

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Acceptable publication but only limited data is given. (number of animals that died not given, symptoms not described; no necropsy; purity of test substance not given).

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

1969

Materials and methods

Principles of method if other than guideline:

Method: according to Smyth, Carpenter, Weil, Pozzani and Striegel: Range-Finding Toxicity Data: List VI, Amer. Ind. Hyg. Assoc. J. 23: 95 (1962), for details see any other information on materials ans methods

GLP compliance:

no

Test type:

standard acute method

Test material

Test material information

Constituent 1

Reference substance name:

2-[2-(3-aminopropoxy)ethoxy]ethanol

EC Number:

203-960-0

EC Name:

2-[2-(3-aminopropoxy)ethoxy]ethanol

Cas Number:

112-33-4

Molecular formula:

C7H17NO3

IUPAC Name:

2-[2-(3-aminopropoxy)ethoxy]ethan-1-ol

Details on test material:

- Name of test material (as cited in study report): 3-Aminopropoxy-2-ethoxy ethanol

Test animals

Species:

rat

Strain:

other: Carworth-Wistar

Sex:

male

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: from own colony at testing lab
- Age at study initiation: 4 to 5 weeks
- Weight at study initiation: 90 to 120 g
- Fasting period before study: not fasted
- Diet: Rockland rat diet, complete; ad libitum

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

other: solution as needed: in water, corn oil or suspension in semi-solid agar (not specified)

Doses:

The dosages are arranged in a logarithmic series differing by a factor of 2. Whenever possible, the chemical is administered undiluted. When a lesser concentration is necessary a suitable vehicle is used.

No. of animals per sex per dose:

5

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: not specified
- Necropsy of survivors performed: no

Statistics:

Based upon mortalities during a 14 day observation period, the most probable LD50 value and its fiducial range are estimated by the method of Thompson (Thompson W.R.: Use of Moving Averages and Interpolation to estimate Median Effective Dose, Bacteriol. Rev. 11: 115, June 1947) using Tables of Weil (Weil C. S.: Tables for convenient calculation of Median-Effective Dose (LD50 or ED50) and Instructions in their Use, Biometrics 8: 249, Sept. 1952).

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LD50

Effect level:

6 500 mg/kg bw

Based on:

test mat.

95% CL:

4 950 - 8 530

Mortality:

no details given

Clinical signs:

other: no details given

Gross pathology:

no necropsy performed