Registration Dossier
Registration Dossier
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EC number: 235-469-2 | CAS number: 12237-63-7 This substance is identified in the Colour Index by Colour Index Constitution Number, C.I. 45160:2.
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Data is from study report.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- The acute inhalation toxicity study was conducted in rats by using test chemical
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Ferrate(4-), hexakis(cyano-C)-, Et 2-[6-(ethylamino)-3-(ethylimino)-2,7-dimethyl-3H-xanthen-9-yl]benzoate copper(2+) salts
- EC Number:
- 235-469-2
- EC Name:
- Ferrate(4-), hexakis(cyano-C)-, Et 2-[6-(ethylamino)-3-(ethylimino)-2,7-dimethyl-3H-xanthen-9-yl]benzoate copper(2+) salts
- Cas Number:
- 12237-63-7
- Molecular formula:
- C34H31N8O3Cu3Fe
- IUPAC Name:
- ferrate(4-), hexakis(cyano-C)-, Et 2-[6-(ethylamino)-3-(ethylimino)-2,7-dimethyl-3H-xanthen-9-yl]benzoate copper(2+) salts
- Details on test material:
- - Name of substance: ferrate(4-), hexakis(cyano-C)-, Et 2-[6-(ethylamino)-3-(ethylimino)-2,7-dimethyl-3H-xanthen-9-yl]benzoate copper(2+) salts
- Appearance : pink solid
- Common name: Pigment red 169
- Substance type: UVCBs-organometallic
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- not specified
- Vehicle:
- air
- Remark on MMAD/GSD:
- not specified
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: desiccator
- Source and rate of air: 200 ltr./air hours - Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 8 h
- Remarks on duration:
- not specified
- Concentrations:
- 3.66 mg/L
- No. of animals per sex per dose:
- Total = 12
- Control animals:
- not specified
- Details on study design:
- - Necropsy of survivors performed: yes, after a week the animals were killed and dissected
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 3.66 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 8 h
- Remarks on result:
- other: No mortality was observed
- Mortality:
- No mortality was obseved at 3.66 mg/L air concentration in treated rats.
- Clinical signs:
- other: Red colored fur was observed.
- Body weight:
- not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The acute inhalation toxicity dose (LC50) value was considered to be >3.66 mg/L air, when 12 male and female rats were treated with test chemical via inhalation route by dust form for 8 hours exposure.
- Executive summary:
The acute inhalation toxicity study was conducted by using test chemical in 12 male and female rats at the dose concentration of 3.66 mg/L via inhalation route by dust form. The desiccator was used as inhalation chamber for animals in which source and rate of air was 200 ltr./air hours. The duration of exposure was 8 hours. Necropsy of survivors performed. After a week the animals were killed and dissected. No mortality was obseved at 3.66 mg/L air concentration in treated rats. Red colored fur was observed. Therefore, LC50 value was considered to be >3.66 mg/L air, when 12 male and female rats were treated with test chemical via inhalation route by dust form for 8 hours exposure.
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