Registration Dossier
Registration Dossier
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EC number: 252-471-9 | CAS number: 35265-04-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 435 (In Vitro Membrane Barrier Test Method for Skin Corrosion)
- Deviations:
- no
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-butylaminoethanol
- EC Number:
- 203-904-5
- EC Name:
- 2-butylaminoethanol
- Cas Number:
- 111-75-1
- IUPAC Name:
- 2-(butylamino)ethanol
- Details on test material:
- Test article name: Butylaminoethanol 1097
test article identification: 95BC12
CAS no. : 111-75-1
Batch no.: H16E
Purity: 99.58% in water
Constituent 1
Results and discussion
In vitro
Results
- Irritation / corrosion parameter:
- other: other: Break through time (minutes)
- Value:
- 40
- Remarks on result:
- other:
- Remarks:
- Remarks: Corrosive (packing group II, or Cat. 1B). (migrated information)
Any other information on results incl. tables
RESULTS OF
PILOT STUDY:
Qualification screen allows CDS use.
Categorization screen allows using the following scoring scale:
Up to 3 minutes: Corrosive (Packing group I)
>3 min but <1h: Corrosive (Packing group II)
>1h but <4h: Corrosive (Packing group III)
>4h: No corrosive
RESULTS OF
TEST
See Attached Document
Applicant's summary and conclusion
- Interpretation of results:
- Category 1B (corrosive)
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- This in vitro test allows to consider 2-butylaminoethanol as corrosive with regard to biomembranes.
- Executive summary:
According to a Corrositex continuous time monitor assay, 2-butylaminoethanol is considered as corrosive category 1B with regard to biomembranes.
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