Registration Dossier
Registration Dossier
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EC number: 307-593-8 | CAS number: 97675-24-6
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
In a primary dermal irritation study , 3 young adult New Zealand white rabbits were dermally exposed to 0.5 ml of sodium 4-icosylbenzenesulfonate for 4 hours. Animals then were observed for 14 days. Irritation was scored by the method of Draize.
Mean scores at 24, 48 and 72 hours for each animal for corneal opacity and iritis was 0 for all animals. Score for conjunctival rednes and oedema werer less than 2 in all of the animals. Therefore, this substance is not irritating to rabbit eyes.
Justification for selection of skin irritation / corrosion endpoint:
In a primary dermal irritation study , 3 young adult New Zealand white rabbits were dermally exposed to 0.5 ml of sodium 4-icosylbenzenesulfonate for 4 hours. Animals then were observed for 14 days. Irritation was scored by the method of Draize.
In this study, sodium 4-icosylbenzenesulfonate is not a dermal irritant.
Justification for selection of eye irritation endpoint:
Mean scores at 24, 48 and 72 hours for each animal for corneal opacity and iritis was 0 for all animals. Score for conjunctival rednes and oedema werer less than 2 in all of the animals. Therefore, this substance is not irritating to rabbit eyes.
Justification for classification or non-classification
In a primary dermal irritation study, 3 young adult New Zealand white rabbitswere dermally exposed to 0.5 mlof sodium 4-icosylbenzenesulfonatefor 4hours. Animals then were observed for 14days. Irritation was scored by the method ofDraize.
In this study, sodium 4-icosylbenzenesulfonate is nota dermal irritant.
Mean scores at 24, 48 and 72 hours for each animal for corneal opacity and iritis was 0 for all animals. Score for conjunctival rednes and oedema werer less than 2 in all of the animals. Therefore, this substance is not irritating to rabbit eyes.
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