Registration Dossier
Registration Dossier
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EC number: 207-274-2 | CAS number: 457-68-1
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion
- Remarks:
- in vitro
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study completed to approved methodology by a cGLP laboratory.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 1,1'-methylenebis[4-fluorobenzene]
- EC Number:
- 207-274-2
- EC Name:
- 1,1'-methylenebis[4-fluorobenzene]
- Cas Number:
- 457-68-1
- Molecular formula:
- C13H10F2
- IUPAC Name:
- 1-fluoro-4-[(4-fluorophenyl)methyl]benzene
Constituent 1
Results and discussion
In vivo
Results
- Irritation parameter:
- other: Direct MTT reduction
- Basis:
- other:
- Time point:
- other: 15minutes
- Score:
- ca. 56.7
- Max. score:
- 100
- Reversibility:
- no data
- Remarks on result:
- other: in vitro study
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
