Registration Dossier
Registration Dossier
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EC number: 207-274-2 | CAS number: 457-68-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Material tested is in a naptha solution and the toxicity evaluated is based on a SG of DFDPM of 0.8g/ml and all deaths are concluded as being due to the DFDPM not the solvent.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: O.E.C.D. Short term and long term tox groups, final report, Paris 1981; ISBN 92-64-12221-4
- GLP compliance:
- not specified
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 1,1'-methylenebis[4-fluorobenzene]
- EC Number:
- 207-274-2
- EC Name:
- 1,1'-methylenebis[4-fluorobenzene]
- Cas Number:
- 457-68-1
- Molecular formula:
- C13H10F2
- IUPAC Name:
- 1-fluoro-4-[(4-fluorophenyl)methyl]benzene
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: unspecified
- Details on oral exposure:
- Directly down a catheter into the lumen of the stomach
- Doses:
- 2-5ml/kg
- No. of animals per sex per dose:
- 4 groups of five males and five females
- Control animals:
- not specified
- Details on study design:
- O.E.C.D. Short term and long term toxicology groups, final report, Paris 1981; ISBN 92-64-12221-4
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 3.8 mL/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 3.1 - <= 4.6
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- ca. 2.8 mL/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 2.2 - <= 3.5
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 3.3 mL/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 2.8 - <= 3.8
Applicant's summary and conclusion
- Interpretation of results:
- sligthly toxic
- Remarks:
- Migrated information Hodge an Sterner 1949 Criteria used for interpretation of results: expert judgment
- Conclusions:
- Classified as Harmful
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