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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1954
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: This study was conducted prior to GLP and test guidelines, but sufficient data is available for interpretation of results

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1954
Report date:
1954

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
None
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium chloride
EC Number:
231-598-3
EC Name:
Sodium chloride
Cas Number:
7647-14-5
Molecular formula:
ClNa
IUPAC Name:
sodium chloride
Details on test material:
- Name of test material (as cited in study report): Sodium Chloride
- Common name: Table salt
- Physical state: White solid granules
- Soluble: Water

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals or test system and environmental conditions:
No data

Test system

Type of coverage:
not specified
Preparation of test site:
other: intact and abraded
Vehicle:
water
Remarks:
for 5%, 10%, 20% and 50 % NaCl solution
Controls:
not specified
Amount / concentration applied:
TEST MATERIAL
- Concentration (if solution): 5%, 10%, 20% and 50 % and 100% NaCl
Duration of treatment / exposure:
No data
Observation period:
No data
Number of animals:
No data
Details on study design:
Please see the table below.

Results and discussion

In vivo

Results
Irritation parameter:
other: The following responses were observed: reddening skin, presence or absence of edema, of necrosis and of scarbs.
Basis:
other: Not specified
Time point:
other: Not specified
Reversibility:
not specified
Remarks on result:
probability of weak irritation
Irritant / corrosive response data:
When in contact with the intact skin, sodium chloride causes no response, either in undiluted form or in solution. However, abraded skin may be appreciably irritated depending upon the concentration of the salt solution. Strong solutions (20% or better) result in scab and scar formation after a few applications. Weaker solutions (10% or 5%) produce slight irritation which delays healing without scarring.
Other effects:
None

Any other information on results incl. tables

None

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
When in contact with the intact skin, sodium chloride causes no response, either in undiluted form or in solution. However, abraded skin may be appreciably irritated depending upon the concentration of the salt solution. Strong solutions (20% or better) result in scab and scar formation after a few applications. Weaker solutions (10% or 5%) produce slight irritation which delays healing without scarring.
Executive summary:

When in contact with the intact skin, sodium chloride causes no response, either in undiluted form or in solution. However, abraded skin may be appreciably irritated depending upon the concentration of the salt solution. Strong solutions (20% or better) result in scab and scar formation after a few applications. Weaker solutions (10% or 5%) produce slight irritation which delays healing without scarring.