Registration Dossier
Registration Dossier
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EC number: 219-823-3 | CAS number: 2544-13-0
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- genetic toxicity in vitro
- Remarks:
- Type of genotoxicity: other: gene mutation and chromosome aberration
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- secondary source
- Title:
- No information
- Year:
- 2 013
- Bibliographic source:
- Daily Med Current Medication Information
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 473 (In Vitro Mammalian Chromosome Aberration Test)
- GLP compliance:
- not specified
- Type of assay:
- other: Ames test and Chromosome aberration test
Test material
- Reference substance name:
- Methyldopa
- EC Number:
- 209-089-2
- EC Name:
- Methyldopa
- Cas Number:
- 555-30-6
- IUPAC Name:
- 3-hydroxy-alpha-methyl-L-tyrosine
Constituent 1
Results and discussion
Test results
- Species / strain:
- not specified
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
Methyldopa was not mutagenic in the Ames Test and did not increase chromosomal aberration or sister chromatid exchanges in Chinese hamster ovary cells. These in vitro studies were carried out both with and without exogenous metabolic activation.
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