Registration Dossier
Registration Dossier
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EC number: 295-653-3 | CAS number: 92113-48-9
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No toxic effects up to the limit of water solubility for Daphnia magna (OECD 211), read across
Key value for chemical safety assessment
Additional information
Since no studies investigating the chronic toxicity towards aquatic invertebrates of Fatty acids, C14-18 and C16-18-unsatd., mixed esters with castor oil, castor oil Fatty acids, 2-ethylhexanoic acid and 2,2-bis(hydroxymethyl)-1-butanol (CAS No. 92113-48-9) are available, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read across to the the structurally similar analogue substance Fatty acids, C14-18 and C16-18 unsatd., triesters with trimethylolpropane (CAS No. 68002-79-9) was conducted. This read-across is justified in detail in the overall summary (IUCLID chapter 6.1) and within the analogue justification in IUCLID Section 13. The read across is justified based on common breakdown products, similar physico-chemical properties, environmental fate, toxicological and ecotoxicological properties.
The read-across study investigated the chronic toxicity of Fatty acids, C16-18 and C18-unsatd., triesters with trimethylolpropane (CAS No. 68002-78-8) to aquatic invertebrates according to OECD 211 (Grell, 2013). Daphnia magna were exposed to the test substance in a semi-static test system. Water accommodated fraction (WAF) were used for preparation of the test solutions. During the exposure period of 21 days mortality and reproduction rate of the test animals were recorded. The substance affected neither the survival rate nor the reproduction rate of D. magna. Based on loading rate a NOELR = 0.11 g/L was determined. Thus toxic effects of C16-18 and C18-unsatd., triesters with trimethylolpropane (CAS No. 68002-78-8) were not observed within the limit of water solubility (WS < 0.05 mg/L).
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