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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1962
Report date:
1962

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Inhalation Hazard Test was performed.
GLP compliance:
no
Test type:
other: Inhalation Hazard Test
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Isodecyl acrylate
EC Number:
215-542-5
EC Name:
Isodecyl acrylate
Cas Number:
1330-61-6
Molecular formula:
C13H24O2
IUPAC Name:
2-methyloctyl prop-2-enoate
Test material form:
liquid

Test animals

Species:
rat
Strain:
other: Carworth Farms-Elias (Albino)
Sex:
female
Details on test animals or test system and environmental conditions:
no

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
air
Details on inhalation exposure:
Concentrated vapor, generated at approx. 21 °C by passind dried air at the rate of 2.5 liters/minute through a fritted glass disc immersed to a depth of al least one inch in 50 ml of isodecyl acrylate. The exposure period was eight-hours in a 9-liter chamber.
Duration of exposure:
8 h
Concentrations:
saturated vapour concentration
No. of animals per sex per dose:
6
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
Statistics:
no

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
other: Inhalation risk test
Effect level:
ca. 333 mg/m³ air
Exp. duration:
8 h
Remarks on result:
other: No mortality occurred
Mortality:
No animals died.
Clinical signs:
other: All Animals appeared to be normal when removed from the inhalation chamber.
Body weight:
All animals gained weight during the subsequent 14-day observation period.
Gross pathology:
no
Other findings:
no

Any other information on results incl. tables

Single Inhalation by a Group of Female Allbino T´Rats of Concentrated Vapor Generated at approx. 21 °C.

Rat Number

Date and duration of Inhalation

Conc. Mg/L

Initial Weight Grams

Weight Change in 14 Days

54929

5-12-62

8 Hours in 9-Liter Chamber

0.3332

138

+44

54931

128

+10

54932

138

+32

54933

144

+21

54934

142

+40

54945

124

+42

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
In an Inhalation Hazard Test, no rats died after an 8 hour-exposure (whole-body) to an atmosphere saturated of isodecyl acrylate (0,3332 mg/L).
Executive summary:

In an Inhalation Hazard Test, no rats died after an 8 hour-exposure (whole-body) to an atmosphere saturated of isodecyl acrylate (0,3332 mg/L). No LC50 was determined.

On the basis of this result, the substance does not warrant classification for an acute inhalation hazard.